Dub-Inhibitors
Catalog number: SBB-PS0032, 50 μg
Ubiquitin-Vinyl Sulfone is a potent and specific inhibitor of deubiquitinating enzymes (DUBs) based on a C-terminal electrophilic Vinyl Sulfone group. Ub-Vinyl Sulfone can be used for activity profiling experiments and DUB inhibitor specificity determination. It targets four of the five major DUB families: UCH, USP, OUT, and MJD, while leaving JAMM metalloproteases uninhibited. Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human Ubiquitin-Vinyl Sulfone concentration of 1-5 μM.
Catalog number: SBB-PS0033, 50 μg
Ubiquitin-Vinyl Methyl Ester is a potent and specific inhibitor of deubiquitinating enzymes (DUBs) based on a C-terminal electrophilic Vinyl Methyl Ester group. Ub-Vinyl Methyl Ester can be used for activity profiling experiments and DUB inhibitor specificity determination. It targets four of the five major DUB families: UCH, USP, OUT, and MJD, while leaving JAMM metalloproteases uninhibited. Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human Ubiquitin- Vinyl Methyl Ester concentration of 1-5 μM.
Catalog number: SBB-PS0034, 50 μg
Ubiquitin- Propargylamideis a potent and specific inhibitor of deubiquitinating enzymes (DUBs) based on a C-terminal electrophilic Propargylamidegroup. Ub- Propargylamidecan be used for activity profiling experiments and DUB inhibitor specificity determination. It targets four of the five major DUB families: UCH, USP, OUT, and MJD, while leaving JAMM metalloproteases uninhibited. Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human Ubiquitin-Propargylamide concentration of 1-5 μM.
Catalog number: SBB-PS0031, 50 μg
Ubiquitin-Aldehyde is a potent and specific inhibitor of deubiquitinating enzymes (DUBs) based on a C-terminal electrophilic Aldehyde group. Ub-Aldehyde can be used for activity profiling experiments and DUB inhibitor specificity determination. It targets four of the five major DUB families: UCH, USP, OUT, and MJD, while leaving JAMM metalloproteases uninhibited. Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human Ubiquitin-Aldehyde concentration of 1-5 μM.
Catalog number: SBB-PS0122, 50 μg
HA-Ubiquitin-Vinyl Sulfone is a potent, irreversible, and specific inhibitor of deubiquitinating enzymes (DUBs) based on a C-terminal electrophilic Vinyl Sulfone group. It targets three of the four major DUB families: UCH (Ubiquitin c-terminal hydrolases), USP (Ubiquitin Specific Proteases), OTU (Ovarian Tumor Proteases), and MJD (Machado-Josephin domain proteases) while JAMM metalloproteases are not inhibited. HA-Ub-Vinyl Sulfone can be used for activity profiling experiments and using the HA-Tag conveniently for Immunoprecipitations in search for new or novel enzymes reacting with the c-terminal warhead.
Catalog Number: SBB-PS0125, 50 μg
HA-Ubiquitin-Vinyl Pentyl Sulfone is a potent, irreversible, and specific inhibitor of deubiquitinating enzymes (DUBs) based on a C-terminal electrophilic VPS group. It targets three of the four major DUB families: UCH (Ubiquitin c-terminal hydrolases), USP (Ubiquitin Specific Proteases), OTU (Ovarian Tumor Proteases), and MJD (Machado-Josephin domain proteases) while JAMM metalloproteases are not inhibited. HA-Ub-Vinyl Pentyl Sulfone can be used for activity profiling experiments and using the HA-Tag conveniently for Immunoprecipitations in search for new or novel enzymes reacting with the c-terminal warhead.
Catalog Number: SBB-PS0123, 50 μg
HA-Ubiquitin-Vinyl Methyl Ester is a potent, irreversible, and specific inhibitor of deubiquitinating enzymes (DUBs) based on a C-terminal electrophilic Vinyl Sulfone group. It targets three of the four major DUB families: UCH (Ubiquitin c-terminal hydrolases), USP (Ubiquitin Specific Proteases), OTU (Ovarian Tumor Proteases), and MJD (Machado-Josephin domain proteases) while JAMM metalloproteases are not inhibited. HA-Ub-Vinyl Methyl ester can be used for activity profiling experiments and using the HA-Tag conveniently for Immunoprecipitations in search for new or novel enzymes reacting with the c-terminal warhead.
Catalog Number: SBB-PS0124, 50ug
HA-Ubiquitin-Propargylamide is a potent, irreversible, and specific inhibitor of deubiquitinating enzymes (DUBs) based on a C-terminal electrophilic Vinyl Sulfone group. It targets three of the four major DUB families: UCH (Ubiquitin c-terminal hydrolases), USP (Ubiquitin Specific Proteases), OTU (Ovarian Tumor Proteases), and MJD (Machado-Josephin domain proteases) while JAMM metalloproteases are not inhibited. HA-Ub-Propargylamide can be used for activity profiling experiments and using the HA-Tag conveniently for Immunoprecipitations in search for new or novel enzymes reacting with the c-terminal warhead.